Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors

• Main Authors: Chang, Shu-Chun, Hsu, Wayne, Su, Emily Chia-Yu, Hung, Chin-Sheng, Ding, Jeak Ling
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Language: English
• Published: MDPI 2021
• Subjects: Science & Technology; Life Sciences & Biomedicine; Oncology; FBXL8 SCF E3 ubiquitin ligase; CCND2; IRF5; breast cancer (BRCA) and metastasis; pro-tumorigenic microenvironment; BREAST-CANCER CELLS; NEDD8-ACTIVATING ENZYME; UBIQUITINATION; CHEMOKINES; INFLAMMATION; RECRUITMENT; PROGRESSION; ACTIVATION; APOPTOSIS; SURVIVAL
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/193718
• Institution: National University of Singapore

10.3390/cancers12082210