MEK1/2 inhibitors unlock the constrained interferon response in macrophages through IRF1 signaling

• Main Authors: Yang, L, Ding, JL
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Language: English
• Published: Frontiers Media SA 2021
• Subjects: IRF1; MAPK; MEK inhibitor; TLR7 agonist; interferon; macrophage; reprogramming; Animals; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Humans; Interferon Regulatory Factor-1; Interferon Regulatory Factors; Interferons; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Macrophages; Melanoma; Mice; Mice, Knockout; Models, Biological; NF-kappa B; Protein Kinase Inhibitors; STAT1 Transcription Factor; Signal Transduction; Toll-Like Receptor 7
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/193730
• Institution: National University of Singapore

10.3389/fimmu.2019.02020