High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

10.1038/s41467-019-13885-w

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Main Authors: Zhang, Y., Chen, F., Fonseca, N.A., He, Y., Fujita, M., Nakagawa, H., Zhang, Z., Brazma, A., Amin, S.B., Awadalla, P., Bailey, P.J., Brooks, A.N., Calabrese, C., Chateigner, A., Cortés-Ciriano, I., Craft, B., Craft, D., Creighton, C.J., Davidson, N.R., Demircioglu, D., Erkek, S., Frenkel-Morgenstern, M., Goldman, M.J., Greger, L., Göke, J., Hoadley, K.A., Hou, Y., Huska, M.R., Kahles, A., Khurana, E., Kilpinen, H., Korbel, J.O., Lamaze, F.C., Lehmann, K.-V., Li, C., Li, S., Li, X., Liu, D., Liu, F., Liu, X., Marin, M.G., Markowski, J., Meyerson, M., Nandi, T., Nielsen, M.M., Ojesina, A.I., Ouellette, B.F.F., Pan-Hammarström, Q., Park, P.J., Pedamallu, C.S., Pedersen, J.S., Perry, M.D., Rätsch, G., Schwarz, R.F., Shiraishi, Y., Siebert, R., Soulette, C.M., Stark, S.G., Stegle, O., Su, H., Tan, P., Teh, B.T., Urban, L., Wang, J., Waszak, S.M., Wu, K., Xiang, Q., Xiong, H., Yakneen, S., Yang, H., Ye, C., Yung, C.K., Zhang, F., Zhang, J., Zhang, X., Zheng, L., Zhu, J., Zhu, S., Akdemir, K.C., Alvarez, E.G., Baez-Ortega, A., Beroukhim, R., Boutros, P.C., Bowtell, D.D.L., Brors, B., Burns, K.H., Campbell, P.J., Chan, K., Chen, K., Dueso-Barroso, A., Dunford, A.J., Edwards, P.A., Estivill, X., Etemadmoghadam, D., Feuerbach, L., Fink, J.L., Garsed, D.W., Gerstein, M., Gordenin, D.A., Haan, D., Haber, J.E., Hess, J.M., Hutter, B., Imielinski, M., Jones, D.T.W., Ju, Y.S., Kazanov, M.D., Klimczak, L.J., Koh, Y., Kumar, K., Lee, E.A., Lee, J.J.-K., Li, Y., Lynch, A.G., Macintyre, G., Markowetz, F., Martincorena, I., Martinez-Fundichely, A., Miyano, S., Navarro, F.C.P., Ossowski, S., Pearson, J.V., Puiggròs, M., Rippe, K., Roberts, N.D., Roberts, S.A., Rodriguez-Martin, B., Schumacher, S.E., Scully, R., Shackleton, M., Sidiropoulos, N., Sieverling, L., Stewart, C., Torrents, D., Tubio, J.M.C., Villasante, I., Waddell, N., Wala, J.A., Weischenfeldt, J., Yang, L., Yao, X., Yoon, S.-S., Zamora, J., Zhang, C.-Z., PCAWG Transcriptome Working Group., PCAWG Structural Variation Working Group., PCAWG Consortium.
Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format: Article
Published: Nature Research 2021
Online Access:https://scholarbank.nus.edu.sg/handle/10635/198087
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institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
description 10.1038/s41467-019-13885-w
author2 DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
author_facet DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Zhang, Y.
Chen, F.
Fonseca, N.A.
He, Y.
Fujita, M.
Nakagawa, H.
Zhang, Z.
Brazma, A.
Amin, S.B.
Awadalla, P.
Bailey, P.J.
Brooks, A.N.
Calabrese, C.
Chateigner, A.
Cortés-Ciriano, I.
Craft, B.
Craft, D.
Creighton, C.J.
Davidson, N.R.
Demircioglu, D.
Erkek, S.
Frenkel-Morgenstern, M.
Goldman, M.J.
Greger, L.
Göke, J.
He, Y.
Hoadley, K.A.
Hou, Y.
Huska, M.R.
Kahles, A.
Khurana, E.
Kilpinen, H.
Korbel, J.O.
Lamaze, F.C.
Lehmann, K.-V.
Li, C.
Li, S.
Li, X.
Li, X.
Liu, D.
Liu, F.
Liu, X.
Marin, M.G.
Markowski, J.
Meyerson, M.
Nandi, T.
Nielsen, M.M.
Ojesina, A.I.
Ouellette, B.F.F.
Pan-Hammarström, Q.
Park, P.J.
Pedamallu, C.S.
Pedersen, J.S.
Perry, M.D.
Rätsch, G.
Schwarz, R.F.
Shiraishi, Y.
Siebert, R.
Soulette, C.M.
Stark, S.G.
Stegle, O.
Su, H.
Tan, P.
Teh, B.T.
Urban, L.
Wang, J.
Waszak, S.M.
Wu, K.
Xiang, Q.
Xiong, H.
Yakneen, S.
Yang, H.
Ye, C.
Yung, C.K.
Zhang, F.
Zhang, J.
Zhang, X.
Zheng, L.
Zhu, J.
Zhu, S.
Akdemir, K.C.
Alvarez, E.G.
Baez-Ortega, A.
Beroukhim, R.
Boutros, P.C.
Bowtell, D.D.L.
Brors, B.
Burns, K.H.
Campbell, P.J.
Chan, K.
Chen, K.
Dueso-Barroso, A.
Dunford, A.J.
Edwards, P.A.
Estivill, X.
Etemadmoghadam, D.
Feuerbach, L.
Fink, J.L.
Garsed, D.W.
Gerstein, M.
Gordenin, D.A.
Haan, D.
Haber, J.E.
Hess, J.M.
Hutter, B.
Imielinski, M.
Jones, D.T.W.
Ju, Y.S.
Kazanov, M.D.
Klimczak, L.J.
Koh, Y.
Kumar, K.
Lee, E.A.
Lee, J.J.-K.
Li, Y.
Lynch, A.G.
Macintyre, G.
Markowetz, F.
Martincorena, I.
Martinez-Fundichely, A.
Miyano, S.
Navarro, F.C.P.
Ossowski, S.
Pearson, J.V.
Puiggròs, M.
Rippe, K.
Roberts, N.D.
Roberts, S.A.
Rodriguez-Martin, B.
Schumacher, S.E.
Scully, R.
Shackleton, M.
Sidiropoulos, N.
Sieverling, L.
Stewart, C.
Torrents, D.
Tubio, J.M.C.
Villasante, I.
Waddell, N.
Wala, J.A.
Weischenfeldt, J.
Yang, L.
Yao, X.
Yoon, S.-S.
Zamora, J.
Zhang, C.-Z.
PCAWG Transcriptome Working Group.
PCAWG Structural Variation Working Group.
PCAWG Consortium.
format Article
author Zhang, Y.
Chen, F.
Fonseca, N.A.
He, Y.
Fujita, M.
Nakagawa, H.
Zhang, Z.
Brazma, A.
Amin, S.B.
Awadalla, P.
Bailey, P.J.
Brooks, A.N.
Calabrese, C.
Chateigner, A.
Cortés-Ciriano, I.
Craft, B.
Craft, D.
Creighton, C.J.
Davidson, N.R.
Demircioglu, D.
Erkek, S.
Frenkel-Morgenstern, M.
Goldman, M.J.
Greger, L.
Göke, J.
He, Y.
Hoadley, K.A.
Hou, Y.
Huska, M.R.
Kahles, A.
Khurana, E.
Kilpinen, H.
Korbel, J.O.
Lamaze, F.C.
Lehmann, K.-V.
Li, C.
Li, S.
Li, X.
Li, X.
Liu, D.
Liu, F.
Liu, X.
Marin, M.G.
Markowski, J.
Meyerson, M.
Nandi, T.
Nielsen, M.M.
Ojesina, A.I.
Ouellette, B.F.F.
Pan-Hammarström, Q.
Park, P.J.
Pedamallu, C.S.
Pedersen, J.S.
Perry, M.D.
Rätsch, G.
Schwarz, R.F.
Shiraishi, Y.
Siebert, R.
Soulette, C.M.
Stark, S.G.
Stegle, O.
Su, H.
Tan, P.
Teh, B.T.
Urban, L.
Wang, J.
Waszak, S.M.
Wu, K.
Xiang, Q.
Xiong, H.
Yakneen, S.
Yang, H.
Ye, C.
Yung, C.K.
Zhang, F.
Zhang, J.
Zhang, X.
Zheng, L.
Zhu, J.
Zhu, S.
Akdemir, K.C.
Alvarez, E.G.
Baez-Ortega, A.
Beroukhim, R.
Boutros, P.C.
Bowtell, D.D.L.
Brors, B.
Burns, K.H.
Campbell, P.J.
Chan, K.
Chen, K.
Dueso-Barroso, A.
Dunford, A.J.
Edwards, P.A.
Estivill, X.
Etemadmoghadam, D.
Feuerbach, L.
Fink, J.L.
Garsed, D.W.
Gerstein, M.
Gordenin, D.A.
Haan, D.
Haber, J.E.
Hess, J.M.
Hutter, B.
Imielinski, M.
Jones, D.T.W.
Ju, Y.S.
Kazanov, M.D.
Klimczak, L.J.
Koh, Y.
Kumar, K.
Lee, E.A.
Lee, J.J.-K.
Li, Y.
Lynch, A.G.
Macintyre, G.
Markowetz, F.
Martincorena, I.
Martinez-Fundichely, A.
Miyano, S.
Navarro, F.C.P.
Ossowski, S.
Pearson, J.V.
Puiggròs, M.
Rippe, K.
Roberts, N.D.
Roberts, S.A.
Rodriguez-Martin, B.
Schumacher, S.E.
Scully, R.
Shackleton, M.
Sidiropoulos, N.
Sieverling, L.
Stewart, C.
Torrents, D.
Tubio, J.M.C.
Villasante, I.
Waddell, N.
Wala, J.A.
Weischenfeldt, J.
Yang, L.
Yao, X.
Yoon, S.-S.
Zamora, J.
Zhang, C.-Z.
PCAWG Transcriptome Working Group.
PCAWG Structural Variation Working Group.
PCAWG Consortium.
spellingShingle Zhang, Y.
Chen, F.
Fonseca, N.A.
He, Y.
Fujita, M.
Nakagawa, H.
Zhang, Z.
Brazma, A.
Amin, S.B.
Awadalla, P.
Bailey, P.J.
Brooks, A.N.
Calabrese, C.
Chateigner, A.
Cortés-Ciriano, I.
Craft, B.
Craft, D.
Creighton, C.J.
Davidson, N.R.
Demircioglu, D.
Erkek, S.
Frenkel-Morgenstern, M.
Goldman, M.J.
Greger, L.
Göke, J.
He, Y.
Hoadley, K.A.
Hou, Y.
Huska, M.R.
Kahles, A.
Khurana, E.
Kilpinen, H.
Korbel, J.O.
Lamaze, F.C.
Lehmann, K.-V.
Li, C.
Li, S.
Li, X.
Li, X.
Liu, D.
Liu, F.
Liu, X.
Marin, M.G.
Markowski, J.
Meyerson, M.
Nandi, T.
Nielsen, M.M.
Ojesina, A.I.
Ouellette, B.F.F.
Pan-Hammarström, Q.
Park, P.J.
Pedamallu, C.S.
Pedersen, J.S.
Perry, M.D.
Rätsch, G.
Schwarz, R.F.
Shiraishi, Y.
Siebert, R.
Soulette, C.M.
Stark, S.G.
Stegle, O.
Su, H.
Tan, P.
Teh, B.T.
Urban, L.
Wang, J.
Waszak, S.M.
Wu, K.
Xiang, Q.
Xiong, H.
Yakneen, S.
Yang, H.
Ye, C.
Yung, C.K.
Zhang, F.
Zhang, J.
Zhang, X.
Zheng, L.
Zhu, J.
Zhu, S.
Akdemir, K.C.
Alvarez, E.G.
Baez-Ortega, A.
Beroukhim, R.
Boutros, P.C.
Bowtell, D.D.L.
Brors, B.
Burns, K.H.
Campbell, P.J.
Chan, K.
Chen, K.
Dueso-Barroso, A.
Dunford, A.J.
Edwards, P.A.
Estivill, X.
Etemadmoghadam, D.
Feuerbach, L.
Fink, J.L.
Garsed, D.W.
Gerstein, M.
Gordenin, D.A.
Haan, D.
Haber, J.E.
Hess, J.M.
Hutter, B.
Imielinski, M.
Jones, D.T.W.
Ju, Y.S.
Kazanov, M.D.
Klimczak, L.J.
Koh, Y.
Kumar, K.
Lee, E.A.
Lee, J.J.-K.
Li, Y.
Lynch, A.G.
Macintyre, G.
Markowetz, F.
Martincorena, I.
Martinez-Fundichely, A.
Miyano, S.
Navarro, F.C.P.
Ossowski, S.
Pearson, J.V.
Puiggròs, M.
Rippe, K.
Roberts, N.D.
Roberts, S.A.
Rodriguez-Martin, B.
Schumacher, S.E.
Scully, R.
Shackleton, M.
Sidiropoulos, N.
Sieverling, L.
Stewart, C.
Torrents, D.
Tubio, J.M.C.
Villasante, I.
Waddell, N.
Wala, J.A.
Weischenfeldt, J.
Yang, L.
Yao, X.
Yoon, S.-S.
Zamora, J.
Zhang, C.-Z.
PCAWG Transcriptome Working Group.
PCAWG Structural Variation Working Group.
PCAWG Consortium.
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
author_sort Zhang, Y.
title High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
title_short High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
title_full High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
title_fullStr High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
title_full_unstemmed High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
title_sort high-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
publisher Nature Research
publishDate 2021
url https://scholarbank.nus.edu.sg/handle/10635/198087
_version_ 1821199079131054080
spelling sg-nus-scholar.10635-1980872024-11-10T17:21:06Z High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations Zhang, Y. Chen, F. Fonseca, N.A. He, Y. Fujita, M. Nakagawa, H. Zhang, Z. Brazma, A. Amin, S.B. Awadalla, P. Bailey, P.J. Brooks, A.N. Calabrese, C. Chateigner, A. Cortés-Ciriano, I. Craft, B. Craft, D. Creighton, C.J. Davidson, N.R. Demircioglu, D. Erkek, S. Frenkel-Morgenstern, M. Goldman, M.J. Greger, L. Göke, J. He, Y. Hoadley, K.A. Hou, Y. Huska, M.R. Kahles, A. Khurana, E. Kilpinen, H. Korbel, J.O. Lamaze, F.C. Lehmann, K.-V. Li, C. Li, S. Li, X. Li, X. Liu, D. Liu, F. Liu, X. Marin, M.G. Markowski, J. Meyerson, M. Nandi, T. Nielsen, M.M. Ojesina, A.I. Ouellette, B.F.F. Pan-Hammarström, Q. Park, P.J. Pedamallu, C.S. Pedersen, J.S. Perry, M.D. Rätsch, G. Schwarz, R.F. Shiraishi, Y. Siebert, R. Soulette, C.M. Stark, S.G. Stegle, O. Su, H. Tan, P. Teh, B.T. Urban, L. Wang, J. Waszak, S.M. Wu, K. Xiang, Q. Xiong, H. Yakneen, S. Yang, H. Ye, C. Yung, C.K. Zhang, F. Zhang, J. Zhang, X. Zheng, L. Zhu, J. Zhu, S. Akdemir, K.C. Alvarez, E.G. Baez-Ortega, A. Beroukhim, R. Boutros, P.C. Bowtell, D.D.L. Brors, B. Burns, K.H. Campbell, P.J. Chan, K. Chen, K. Dueso-Barroso, A. Dunford, A.J. Edwards, P.A. Estivill, X. Etemadmoghadam, D. Feuerbach, L. Fink, J.L. Garsed, D.W. Gerstein, M. Gordenin, D.A. Haan, D. Haber, J.E. Hess, J.M. Hutter, B. Imielinski, M. Jones, D.T.W. Ju, Y.S. Kazanov, M.D. Klimczak, L.J. Koh, Y. Kumar, K. Lee, E.A. Lee, J.J.-K. Li, Y. Lynch, A.G. Macintyre, G. Markowetz, F. Martincorena, I. Martinez-Fundichely, A. Miyano, S. Navarro, F.C.P. Ossowski, S. Pearson, J.V. Puiggròs, M. Rippe, K. Roberts, N.D. Roberts, S.A. Rodriguez-Martin, B. Schumacher, S.E. Scully, R. Shackleton, M. Sidiropoulos, N. Sieverling, L. Stewart, C. Torrents, D. Tubio, J.M.C. Villasante, I. Waddell, N. Wala, J.A. Weischenfeldt, J. Yang, L. Yao, X. Yoon, S.-S. Zamora, J. Zhang, C.-Z. PCAWG Transcriptome Working Group. PCAWG Structural Variation Working Group. PCAWG Consortium. DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL 10.1038/s41467-019-13885-w Nature Communications 11 1 736 2021-08-19T04:35:09Z 2021-08-19T04:35:09Z 2020 Article Zhang, Y., Chen, F., Fonseca, N.A., He, Y., Fujita, M., Nakagawa, H., Zhang, Z., Brazma, A., Amin, S.B., Awadalla, P., Bailey, P.J., Brooks, A.N., Calabrese, C., Chateigner, A., Cortés-Ciriano, I., Craft, B., Craft, D., Creighton, C.J., Davidson, N.R., Demircioglu, D., Erkek, S., Frenkel-Morgenstern, M., Goldman, M.J., Greger, L., Göke, J., He, Y., Hoadley, K.A., Hou, Y., Huska, M.R., Kahles, A., Khurana, E., Kilpinen, H., Korbel, J.O., Lamaze, F.C., Lehmann, K.-V., Li, C., Li, S., Li, X., Li, X., Liu, D., Liu, F., Liu, X., Marin, M.G., Markowski, J., Meyerson, M., Nandi, T., Nielsen, M.M., Ojesina, A.I., Ouellette, B.F.F., Pan-Hammarström, Q., Park, P.J., Pedamallu, C.S., Pedersen, J.S., Perry, M.D., Rätsch, G., Schwarz, R.F., Shiraishi, Y., Siebert, R., Soulette, C.M., Stark, S.G., Stegle, O., Su, H., Tan, P., Teh, B.T., Urban, L., Wang, J., Waszak, S.M., Wu, K., Xiang, Q., Xiong, H., Yakneen, S., Yang, H., Ye, C., Yung, C.K., Zhang, F., Zhang, J., Zhang, X., Zheng, L., Zhu, J., Zhu, S., Akdemir, K.C., Alvarez, E.G., Baez-Ortega, A., Beroukhim, R., Boutros, P.C., Bowtell, D.D.L., Brors, B., Burns, K.H., Campbell, P.J., Chan, K., Chen, K., Dueso-Barroso, A., Dunford, A.J., Edwards, P.A., Estivill, X., Etemadmoghadam, D., Feuerbach, L., Fink, J.L., Garsed, D.W., Gerstein, M., Gordenin, D.A., Haan, D., Haber, J.E., Hess, J.M., Hutter, B., Imielinski, M., Jones, D.T.W., Ju, Y.S., Kazanov, M.D., Klimczak, L.J., Koh, Y., Kumar, K., Lee, E.A., Lee, J.J.-K., Li, Y., Lynch, A.G., Macintyre, G., Markowetz, F., Martincorena, I., Martinez-Fundichely, A., Miyano, S., Navarro, F.C.P., Ossowski, S., Pearson, J.V., Puiggròs, M., Rippe, K., Roberts, N.D., Roberts, S.A., Rodriguez-Martin, B., Schumacher, S.E., Scully, R., Shackleton, M., Sidiropoulos, N., Sieverling, L., Stewart, C., Torrents, D., Tubio, J.M.C., Villasante, I., Waddell, N., Wala, J.A., Weischenfeldt, J., Yang, L., Yao, X., Yoon, S.-S., Zamora, J., Zhang, C.-Z., PCAWG Transcriptome Working Group., PCAWG Structural Variation Working Group., PCAWG Consortium. (2020). High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nature Communications 11 (1) : 736. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-13885-w 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/198087 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Research Scopus OA2020