Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery

10.3390/ph15010012

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Main Authors: Krishna Deepak, RNV, Verma, Ravi Kumar, Hartono, Yossa Dwi, Yew, Wen Shan, Fan, Hao
Other Authors: BIOCHEMISTRY
Format: Article
Language:English
Published: MDPI 2022
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Online Access:https://scholarbank.nus.edu.sg/handle/10635/218856
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Institution: National University of Singapore
Language: English
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spelling sg-nus-scholar.10635-2188562024-04-16T05:27:28Z Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery Krishna Deepak, RNV Verma, Ravi Kumar Hartono, Yossa Dwi Yew, Wen Shan Fan, Hao BIOCHEMISTRY BIOLOGICAL SCIENCES Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy lipid GPCR ligand access orthosteric and allosteric binding sites drug discovery antibody computational methods prostaglandin receptor platelet-activating factor receptor sphingosine-1-phosphate receptor lysophosphatidic acid receptor leukotriene receptor free fatty acid receptor cannabinoid receptor PROTEIN-COUPLED RECEPTOR STABILIZED ACTIVE STATE CRYO-EM STRUCTURE CRYSTAL-STRUCTURE ALLOSTERIC MODULATION LIGAND-BINDING ACTIVATION MECHANISMS INSIGHTS SITES 10.3390/ph15010012 PHARMACEUTICALS 15 1 2022-04-11T06:50:02Z 2022-04-11T06:50:02Z 2022-01-01 2022-04-11T02:56:33Z Article Krishna Deepak, RNV, Verma, Ravi Kumar, Hartono, Yossa Dwi, Yew, Wen Shan, Fan, Hao (2022-01-01). Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery. PHARMACEUTICALS 15 (1). ScholarBank@NUS Repository. https://doi.org/10.3390/ph15010012 14248247 https://scholarbank.nus.edu.sg/handle/10635/218856 en MDPI Elements
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
language English
topic Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
lipid GPCR
ligand access
orthosteric and allosteric binding sites
drug discovery
antibody
computational methods
prostaglandin receptor
platelet-activating factor receptor
sphingosine-1-phosphate receptor
lysophosphatidic acid receptor
leukotriene receptor
free fatty acid receptor
cannabinoid receptor
PROTEIN-COUPLED RECEPTOR
STABILIZED ACTIVE STATE
CRYO-EM STRUCTURE
CRYSTAL-STRUCTURE
ALLOSTERIC MODULATION
LIGAND-BINDING
ACTIVATION
MECHANISMS
INSIGHTS
SITES
spellingShingle Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
lipid GPCR
ligand access
orthosteric and allosteric binding sites
drug discovery
antibody
computational methods
prostaglandin receptor
platelet-activating factor receptor
sphingosine-1-phosphate receptor
lysophosphatidic acid receptor
leukotriene receptor
free fatty acid receptor
cannabinoid receptor
PROTEIN-COUPLED RECEPTOR
STABILIZED ACTIVE STATE
CRYO-EM STRUCTURE
CRYSTAL-STRUCTURE
ALLOSTERIC MODULATION
LIGAND-BINDING
ACTIVATION
MECHANISMS
INSIGHTS
SITES
Krishna Deepak, RNV
Verma, Ravi Kumar
Hartono, Yossa Dwi
Yew, Wen Shan
Fan, Hao
Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
description 10.3390/ph15010012
author2 BIOCHEMISTRY
author_facet BIOCHEMISTRY
Krishna Deepak, RNV
Verma, Ravi Kumar
Hartono, Yossa Dwi
Yew, Wen Shan
Fan, Hao
format Article
author Krishna Deepak, RNV
Verma, Ravi Kumar
Hartono, Yossa Dwi
Yew, Wen Shan
Fan, Hao
author_sort Krishna Deepak, RNV
title Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
title_short Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
title_full Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
title_fullStr Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
title_full_unstemmed Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
title_sort recent advances in structure, function, and pharmacology of class a lipid gpcrs: opportunities and challenges for drug discovery
publisher MDPI
publishDate 2022
url https://scholarbank.nus.edu.sg/handle/10635/218856
_version_ 1800915360878166016