Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery

Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery

10.3390/ph15010012

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Bibliographic Details
Main Authors: Krishna Deepak, RNV, Verma, Ravi Kumar, Hartono, Yossa Dwi, Yew, Wen Shan, Fan, Hao
Other Authors: BIOCHEMISTRY
Format: Article
Language:English
Published: MDPI 2022
Subjects:
Science & Technology
Life Sciences & Biomedicine
Chemistry, Medicinal
Pharmacology & Pharmacy
lipid GPCR
ligand access
orthosteric and allosteric binding sites
drug discovery
antibody
computational methods
prostaglandin receptor
platelet-activating factor receptor
sphingosine-1-phosphate receptor
lysophosphatidic acid receptor
leukotriene receptor
free fatty acid receptor
cannabinoid receptor
PROTEIN-COUPLED RECEPTOR
STABILIZED ACTIVE STATE
CRYO-EM STRUCTURE
CRYSTAL-STRUCTURE
ALLOSTERIC MODULATION
LIGAND-BINDING
ACTIVATION
MECHANISMS
INSIGHTS
SITES
Online Access:https://scholarbank.nus.edu.sg/handle/10635/218856
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Institution: National University of Singapore
Language: English

Internet

https://scholarbank.nus.edu.sg/handle/10635/218856

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