THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors

THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors

10.3390/ijms23031207

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Bibliographic Details
Main Authors:	Shyamsunder, Pavithra, Sridharan, Shree Pooja, Madan, Vikas, Dakle, Pushkar, Zeya, Cao, Kanojia, Deepika, Chng, Wee-Joo, Ong, S Tiong, Koeffler, H Phillip
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry DNA repair BRCAness THZ531 Olaparib DEPENDENT KINASE INHIBITOR STRAND BREAK REPAIR HOMOLOGOUS RECOMBINATION GENOMIC STABILITY CDK12 INHIBITION DAMAGE RESPONSE PROTEIN-KINASE WILD-TYPE EXPRESSION RESISTANCE
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/228992
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Institution:	National University of Singapore
Language:	English

Description
Summary:	10.3390/ijms23031207