THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors

• Main Authors: Shyamsunder, Pavithra, Sridharan, Shree Pooja, Madan, Vikas, Dakle, Pushkar, Zeya, Cao, Kanojia, Deepika, Chng, Wee-Joo, Ong, S Tiong, Koeffler, H Phillip
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Language: English
• Published: MDPI 2022
• Subjects: Science & Technology; Life Sciences & Biomedicine; Physical Sciences; Biochemistry & Molecular Biology; Chemistry, Multidisciplinary; Chemistry; DNA repair; BRCAness; THZ531; Olaparib; DEPENDENT KINASE INHIBITOR; STRAND BREAK REPAIR; HOMOLOGOUS RECOMBINATION; GENOMIC STABILITY; CDK12 INHIBITION; DAMAGE RESPONSE; PROTEIN-KINASE; WILD-TYPE; EXPRESSION; RESISTANCE
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/228992
• Institution: National University of Singapore

10.3390/ijms23031207