Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

• Main Authors: Elgaher, Walid AM, Sharma, Kamal K, Haupenthal, Joerg, Saladini, Francesco, Pires, Manuel, Real, Eleonore, Mely, Yves, Hartmann, Rolf W
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Language: English
• Published: AMER CHEMICAL SOC 2023
• Subjects: Science & Technology; Life Sciences & Biomedicine; Chemistry, Medicinal; Pharmacology & Pharmacy; IMMUNODEFICIENCY-VIRUS TYPE-1; FRET-BASED ASSAY; NONNUCLEOSIDE INHIBITORS; DRUG-RESISTANCE; SWITCH REGION; ANGSTROM RESOLUTION; CRYSTAL-STRUCTURE; HIV-1 RT; MECHANISM; BINDING
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/242857
• Institution: National University of Singapore

10.1021/acs.jmedchem.6b00730