Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

10.1021/acs.jmedchem.6b00730

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Bibliographic Details
Main Authors:	Elgaher, Walid AM, Sharma, Kamal K, Haupenthal, Joerg, Saladini, Francesco, Pires, Manuel, Real, Eleonore, Mely, Yves, Hartmann, Rolf W
Other Authors:	BIOLOGICAL SCIENCES
Format:	Article
Language:	English
Published:	AMER CHEMICAL SOC 2023
Subjects:	Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy IMMUNODEFICIENCY-VIRUS TYPE-1 FRET-BASED ASSAY NONNUCLEOSIDE INHIBITORS DRUG-RESISTANCE SWITCH REGION ANGSTROM RESOLUTION CRYSTAL-STRUCTURE HIV-1 RT MECHANISM BINDING
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/242857
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Institution:	National University of Singapore
Language:	English

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Summary:	10.1021/acs.jmedchem.6b00730