Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

10.1021/acs.jmedchem.6b00730

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Main Authors:	Elgaher, Walid AM, Sharma, Kamal K, Haupenthal, Joerg, Saladini, Francesco, Pires, Manuel, Real, Eleonore, Mely, Yves, Hartmann, Rolf W
Other Authors:	BIOLOGICAL SCIENCES
Format:	Article
Language:	English
Published:	AMER CHEMICAL SOC 2023
Subjects:	Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy IMMUNODEFICIENCY-VIRUS TYPE-1 FRET-BASED ASSAY NONNUCLEOSIDE INHIBITORS DRUG-RESISTANCE SWITCH REGION ANGSTROM RESOLUTION CRYSTAL-STRUCTURE HIV-1 RT MECHANISM BINDING
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/242857
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Institution:	National University of Singapore
Language:	English

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spelling	sg-nus-scholar.10635-2428572023-11-01T08:42:05Z Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors Elgaher, Walid AM Sharma, Kamal K Haupenthal, Joerg Saladini, Francesco Pires, Manuel Real, Eleonore Mely, Yves Hartmann, Rolf W BIOLOGICAL SCIENCES Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy IMMUNODEFICIENCY-VIRUS TYPE-1 FRET-BASED ASSAY NONNUCLEOSIDE INHIBITORS DRUG-RESISTANCE SWITCH REGION ANGSTROM RESOLUTION CRYSTAL-STRUCTURE HIV-1 RT MECHANISM BINDING 10.1021/acs.jmedchem.6b00730 JOURNAL OF MEDICINAL CHEMISTRY 59 15 7212-7222 2023-07-06T11:16:02Z 2023-07-06T11:16:02Z 2016-08-11 2023-07-06T08:09:07Z Article Elgaher, Walid AM, Sharma, Kamal K, Haupenthal, Joerg, Saladini, Francesco, Pires, Manuel, Real, Eleonore, Mely, Yves, Hartmann, Rolf W (2016-08-11). Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY 59 (15) : 7212-7222. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.jmedchem.6b00730 0022-2623 1520-4804 https://scholarbank.nus.edu.sg/handle/10635/242857 en AMER CHEMICAL SOC Elements
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
language	English
topic	Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy IMMUNODEFICIENCY-VIRUS TYPE-1 FRET-BASED ASSAY NONNUCLEOSIDE INHIBITORS DRUG-RESISTANCE SWITCH REGION ANGSTROM RESOLUTION CRYSTAL-STRUCTURE HIV-1 RT MECHANISM BINDING
spellingShingle	Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy IMMUNODEFICIENCY-VIRUS TYPE-1 FRET-BASED ASSAY NONNUCLEOSIDE INHIBITORS DRUG-RESISTANCE SWITCH REGION ANGSTROM RESOLUTION CRYSTAL-STRUCTURE HIV-1 RT MECHANISM BINDING Elgaher, Walid AM Sharma, Kamal K Haupenthal, Joerg Saladini, Francesco Pires, Manuel Real, Eleonore Mely, Yves Hartmann, Rolf W Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
description	10.1021/acs.jmedchem.6b00730
author2	BIOLOGICAL SCIENCES
author_facet	BIOLOGICAL SCIENCES Elgaher, Walid AM Sharma, Kamal K Haupenthal, Joerg Saladini, Francesco Pires, Manuel Real, Eleonore Mely, Yves Hartmann, Rolf W
format	Article
author	Elgaher, Walid AM Sharma, Kamal K Haupenthal, Joerg Saladini, Francesco Pires, Manuel Real, Eleonore Mely, Yves Hartmann, Rolf W
author_sort	Elgaher, Walid AM
title	Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
title_short	Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
title_full	Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
title_fullStr	Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
title_full_unstemmed	Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
title_sort	discovery and structure-based optimization of 2-ureidothiophene-3-carboxylic acids as dual bacterial rna polymerase and viral reverse transcriptase inhibitors
publisher	AMER CHEMICAL SOC
publishDate	2023
url	https://scholarbank.nus.edu.sg/handle/10635/242857
_version_	1781793545284222976

Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

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