Early stopping by using stochastic curtailment in a three-arm sequential trial

• Main Authors: LEUNG, Denis H. Y., WANG, You-Gan, AMAR, David
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2003
• Subjects: Bonferroni adjustment; Conditional power; Interim analysis; Predictive power; Stochastic curtailment; Stopping time; Econometrics
• Online Access: https://ink.library.smu.edu.sg/soe_research/106; https://ink.library.smu.edu.sg/context/soe_research/article/1105/viewcontent/Leung_et_al_2003_Early_Stopping.pdf
• Institution: Singapore Management University

Interim analysis is important in a large clinical trial for ethical and cost considerations. Sometimes, an interim analysis needs to be performed at an earlier than planned time point. In that case, methods using stochastic curtailment are useful in examining the data for early stopping while contro...