Phase I and Pharmacokinetic Study of 10-Propargyl-10-Deazaaminopterin, a New Antifolate

• Main Authors: Krug, L., Kris, M., Miller, V., Tong, W., Heelan, R., Leon, L., Leung, Denis H. Y., Kelly, J., Grant, S., Sirotnak, F.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2000
• Subjects: Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/480
• Institution: Singapore Management University

The 10-deazaaminopterins are a new class of rationally designed antifolates demonstrating greater antitumor effects than methotrexate in murine tumor models and human tumor xenografts. Their design was aimed at improving membrane transport and polyglutamylation in tumor cells, resulting in increased...