Phase I and Pharmacokinetic Study of 10-Propargyl-10-Deazaaminopterin, a New Antifolate
The 10-deazaaminopterins are a new class of rationally designed antifolates demonstrating greater antitumor effects than methotrexate in murine tumor models and human tumor xenografts. Their design was aimed at improving membrane transport and polyglutamylation in tumor cells, resulting in increased...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | text |
| Language: | English |
| Published: |
Institutional Knowledge at Singapore Management University
2000
|
| Subjects: | |
| Online Access: | https://ink.library.smu.edu.sg/soe_research/480 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Singapore Management University |
| Language: | English |