Extension of three-arm non-inferiority studies to trials with multiple new treatments

Extension of three-arm non-inferiority studies to trials with multiple new treatments

Non-inferiority (NI) trials are becoming increasingly popular. The main purpose of NI trials is to assert the efficacy of a new treatment compared with an active control by demonstrating that the new treatment maintains a substantial fraction of the treatment effect of the control. Most of the stati...

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Bibliographic Details
Main Authors: KWONG, Koon Shing, CHEUNG, Siu Hung, HAYTER, Anthony J., WEN, Minn-Jye
Format: text
Language:English
Published: Institutional Knowledge at Singapore Management University 2012
Subjects:
three-arm design
non-inferiority trial
control treatment
placebo
familywise error rate
assay sensitivity
pre-specified non-inferiority margin
Econometrics
Health Economics
Online Access:https://ink.library.smu.edu.sg/soe_research/1411
https://doi.org/10.1002/sim.5467
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Institution: Singapore Management University
Language: English

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https://ink.library.smu.edu.sg/soe_research/1411
https://doi.org/10.1002/sim.5467

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