Extension of three-arm non-inferiority studies to trials with multiple new treatments

• Main Authors: KWONG, Koon Shing, CHEUNG, Siu Hung, HAYTER, Anthony J., WEN, Minn-Jye
• 格式: text
• 語言: English
• 出版: Institutional Knowledge at Singapore Management University 2012
• 主題: three-arm design; non-inferiority trial; control treatment; placebo; familywise error rate; assay sensitivity; pre-specified non-inferiority margin; Econometrics; Health Economics
• 在線閱讀: https://ink.library.smu.edu.sg/soe_research/1411; https://doi.org/10.1002/sim.5467
• 機構: Singapore Management University

Non-inferiority (NI) trials are becoming increasingly popular. The main purpose of NI trials is to assert the efficacy of a new treatment compared with an active control by demonstrating that the new treatment maintains a substantial fraction of the treatment effect of the control. Most of the stati...