Step-up procedures for non-inferiority tests with multiple experimental treatments

• Main Authors: KWONG, Koon Shing, CHEUNG, Siu Hung, HAYTER, Anthony J.
• 格式: text
• 語言: English
• 出版: Institutional Knowledge at Singapore Management University 2016
• 主題: assay sensitivity; control treatment; Familywise error rate; non-inferiority trial; placebo; stepwise procedure; Econometrics; Health Economics
• 在線閱讀: https://ink.library.smu.edu.sg/soe_research/1494; https://doi.org/10.1177/0962280213477767
• 機構: Singapore Management University

Non-inferiority (NI) trials are becoming more popular. The NI of a new treatment compared with a standard treatment is established when the new treatment maintains a substantial fraction of the treatment effect of the standard treatment. A valid NI trial is also required to show assay sensitivity, t...