Step-up procedures for non-inferiority tests with multiple experimental treatments

• Main Authors: KWONG, Koon Shing, CHEUNG, Siu Hung, HAYTER, Anthony J.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2016
• Subjects: assay sensitivity; control treatment; Familywise error rate; non-inferiority trial; placebo; stepwise procedure; Econometrics; Health Economics
• Online Access: https://ink.library.smu.edu.sg/soe_research/1494; https://doi.org/10.1177/0962280213477767
• Institution: Singapore Management University

Non-inferiority (NI) trials are becoming more popular. The NI of a new treatment compared with a standard treatment is established when the new treatment maintains a substantial fraction of the treatment effect of the standard treatment. A valid NI trial is also required to show assay sensitivity, t...