Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: A molecular and clinicopathologic study of 82 cases

• Main Authors: Antonescu, C. R., Tschernyavsky, S. J., Decuseara, R., LEUNG, Denis H. Y., Woodruff, J. M., Brennan, M. F., Bridge, J. A., Neff, J. R., Goldblum, J. R., Ladanyi, M.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2001
• Subjects: protein p53; cancer; Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/2488; https://ink.library.smu.edu.sg/context/soe_research/article/3487/viewcontent/P53_CCR_3977.full_2001_pv.pdf
• Institution: Singapore Management University

Purpose: A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS). Three common forms of the TLS-CHOP fusion have been described, differing by the presence or absence of TLS exons 6-8 in the fusion product. Type 5-2 (also known as type II) c...