T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice

• المؤلفون الرئيسيون: Kumfu S., Chattipakorn S., Chinda K., Fucharoen S., Chattipakorn N.
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الوصول للمادة أونلاين: http://www.ncbi.nlm.nih.gov/pubmed/22404220; http://www.scopus.com/inward/record.url?eid=2-s2.0-84861187773&partnerID=40&md5=78f28a0e653c58cc846780452cd70ea0; http://cmuir.cmu.ac.th/handle/6653943832/1075
• المؤسسة: Chiang Mai University

Objectives: Iron-overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron entry and sequestration in the heart are still unclear. Our previous study showed that Fe 2+ uptake in thalassemic cardiomyocytes are mainly medi...