Calcium-induced Cardiac Mitochondrial Dysfunction Is Predominantly Mediated by Cyclosporine A-dependent Mitochondrial Permeability Transition Pore

• Main Authors: Yarana C., Sripetchwandee J., Sanit J., Chattipakorn S., Chattipakorn N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84866143717&partnerID=40&md5=4c770efa2534432db96db5eaf7d2a985; http://cmuir.cmu.ac.th/handle/6653943832/1155
• Institution: Chiang Mai University

Background and Aims: Cardiac mitochondrial Ca 2+ overload plays a critical role in mechanical and electrical dysfunction leading to cardiac cell death and fatal arrhythmia. Because Ca 2+ overload is related to mitochondrial permeability transition, reactive oxygen species (ROS) production and membra...