Differential modulation of prM cleavage, extracellular particle distribution, and virus infectivity by conserved residues at nonfurin consensus positions of the dengue virus pr-M junction

• Main Authors: Junjhon J., Lausumpao M., Supasa S., Noisakran S., Songjaeng A., Saraithong P., Chaichoun K., Utaipat U., Keelapang P., Kanjanahaluethai A., Puttikhunt C., Kasinrerk W., Malasit P., Sittisombut N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-55249088356&partnerID=40&md5=f036e0ddcdffe8013886df509cf556b4; http://www.ncbi.nlm.nih.gov/pubmed/18715923; http://cmuir.cmu.ac.th/handle/6653943832/2345
• Institution: Chiang Mai University

In the generation of flavivirus particles, an internal cleavage of the envelope glycoprotein prM by furin is required for the acquisition of infectivity. Unlike cleavage of the prM of other flaviviruses, cleavage of dengue virus prM is incomplete in many cell lines; the partial cleavage reflects the...