Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance

• Main Authors: Chanmahasathien W., Ampasavate C., Greger H., Limtrakul P.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651336302&partnerID=40&md5=bb972698761568a8a72c9881acfb619e; http://www.ncbi.nlm.nih.gov/pubmed/20739156; http://cmuir.cmu.ac.th/handle/6653943832/2718

P-glycoprotein-mediated drug efflux can cause a multidrug resistance (MDR) phenotype that is associated with a poor response to cancer chemotherapy. Through bioassay-guided fractionation, active Stemona alkaloids were isolated from the roots of Stemona aphylla and S. burkillii. The chemical structur...