Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: Implications for preimplantation genetic diagnosis
Preimplantation genetic diagnosis (PGD) of single gene disorders relies on PCR-based tests performed on single cells (polar bodies or blastomeres). Despite the use of increasingly robust protocols, allele drop-out (ADO; the failure to amplify one of the two alleles in a heterozygous cell) remains a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0038148733&partnerID=40&md5=254d2a986b0e4acfafb9992324491855 http://cmuir.cmu.ac.th/handle/6653943832/2987 |
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| Institution: | Chiang Mai University |
| Language: | English |