Biochemical mechanism of modulation of human p-glycoprotein by stemofoline

• Main Authors: Chanmahasathien,W., Ohnuma,S., Ambudkar,S.V., Limtrakul,P.N.
• Format: Article
• Published: Georg Thieme Verlag 2015
• Subjects: Analytical Chemistry; Drug Discovery; Pharmaceutical Science; Molecular Medicine; Pharmacology; Organic Chemistry; Complementary and Alternative Medicine
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84155172846&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38520
• Institution: Chiang Mai University

The resistance to chemotherapeutic drugs by cancer cells is considered to be one of the major obstacles for success in the treatment of cancer. A major mechanism underlying this multidrug resistance is the overexpression of P-glycoprotein (P-gp), resulting in insufficient drug delivery to the tumor...