A sample size calculation of Bayesian design for superiority trials with rare events

• Main Authors: Sripan P., Ingsrisawang L., Amzal B., Le Ccur S., Cressey T., Lallemant M., Urien S.
• Format: Conference Proceeding
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84978708523&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/42657
• Institution: Chiang Mai University

Traditional approaches used in sample calculation for superiority trials comparing two low proportions usually provide very large sample sizes. Furthermore, such calculations may be inaccurate due to asymptotic normality that is often assumed but may not hold in such cases. Bayesian approach could r...