Alterations of pr-M Cleavage and Virus Export in pr-M Junction Chimeric Dengue Viruses

• Main Authors: Keelapang P., Sriburi R., Supasa S., Panyadee N., Songjaeng A., Jairungsri A., Puttikhunt C., Kasinrerk W., Malasit P., Sittisombut N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-10744223893&partnerID=40&md5=0c2743a8876d115339690faa337854e3; http://cmuir.cmu.ac.th/handle/6653943832/4283
• Institution: Chiang Mai University

During the export of flavivirus particles through the secretory pathway, a viral envelope glycoprotein, prM, is cleaved by the proprotein convertase furin; this cleavage is required for the subsequent rearrangement of receptor-binding E glycoprotein and for virus infectivity. Similar to many furin s...