Development of suspending agent from sodium carboxymethyl mungbean starches

• Main Authors: Kittipongpatana O.S., Sirithunyalug J.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-33747626260&partnerID=40&md5=4278333ee58f3ee5cba1030302a8c86f; http://www.ncbi.nlm.nih.gov/pubmed/16908418; http://cmuir.cmu.ac.th/handle/6653943832/4441
• Institution: Chiang Mai University

Three sodium carboxymethyl mungbean starches (SCMMSs) were selected, based on the physicochemical profiles and evaluated as potential pharmaceutical suspending agent in comparison with a sodium carboxymethyl tapioca starch and other five commercial suspending agents. Ibuprofen suspension was employed as a model formulation with 0.5, 1.0, and 2.0% w/v of suspending agents. Evaluation parameters included the determination of sedimentation volume ratio, redispersibility, viscosity and rheological properties and content uniformity studies. The results revealed that a high-viscosity modified mungbean starch, MMS-M-04, possessed suitable properties as a suspending agent and, at 1% concentration, was as effective as sodium carboxymethylcellulose and xanthan gum, two most-commonly used suspending agents. This modified starch could be further developed and employed as a new commercial suspending agent in the pharmaceutical industry. Copyright © Informa Healthcare.