Effects of Curcuma spp. on P-glycoprotein function

• Main Authors: Ampasavate C., Sotanaphun U., Phattanawasin P., Piyapolrungroj N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77950867304&partnerID=40&md5=88078a4a19638daa7633b80678f91e9b; http://www.ncbi.nlm.nih.gov/pubmed/19879740; http://cmuir.cmu.ac.th/handle/6653943832/4502
• Institution: Chiang Mai University

The effects of Curcuma longa (khamin chan) and Curcuma sp. "khamin-oi" (khamin-oi), as well as isolated major curcuminoids on intestinal P-gp functions were evaluated in vitro. The accumulation of R123 in Caco-2 cells was increased and the R123 efflux ratios were significantly decreased by...