EMMPRIN reduction via scFv-M6-1B9 intrabody affects α3β1- integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2

• Main Authors: S. Sangboonruang, P. Thammasit, N. Intasai, W. Kasinrerk, C. Tayapiwatana, K. Tragoolpua
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903593918&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/45468
• Institution: Chiang Mai University

Extracellular matrix metalloproteinase inducer (EMMPRIN) exhibits overexpression in various cancers and promotes cancer progression and metastasis via the interaction with its associated molecules. The scFv-M6-1B9 intrabody has a potential ability to reduce EMMPRIN cell surface expression. However,...