ATF6α induces XBP1-independent expansion of the endoplasmic reticulum

• Main Authors: Hemamalini Bommiasamy, Sung Hoon Back, Paolo Fagone, Kyungho Lee, Sasha Meshinchi, Elizabeth Vink, Rungtawan Sriburi, Matthew Frank, Suzanne Jackowski, Randal J. Kaufman, Joseph W. Brewer
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650000500&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/48876
• Institution: Chiang Mai University

A link exists between endoplasmic reticulum (ER) biogenesis and the unfolded protein response (UPR), a complex set of signaling mechanisms triggered by increased demands on the protein folding capacity of the ER. The UPR transcriptional activator X-box binding protein 1 (XBP1) regulates the expressi...