Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis

• Main Authors: Rungtawan Sriburi, Hemamalini Bommiasamy, Gerald L. Buldak, Gregory R. Robbins, Matthew Frank, Suzanne Jackowski, Joseph W. Brewer
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34147172715&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60915
• Institution: Chiang Mai University

Development of the expansive endoplasmic reticulum (ER) present in specialized secretory cell types requires X-box-binding protein-1 (Xbp-1). Enforced expression of XBP-1(S), a transcriptional activator generated by unfolded protein response-mediated splicing of Xbp-1 mRNA, is sufficient to induce p...