Phospholipid biosynthesis program underlying membrane expansion during B-lymphocyte differentiation

• Main Authors: Paolo Fagone, Rungtawan Sriburi, Cheryl Ward-Chapman, Matthew Frank, Jina Wang, Christopher Gunter, Joseph W. Brewer, Suzanne Jackowski
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34147124116&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60914
• Institution: Chiang Mai University

Stimulated B-lymphocytes differentiate into plasma cells committed to antibody production. Expansion of the endoplasmic reticulum and Golgi compartments is a prerequisite for high rate synthesis, assembly, and secretion of immunoglobulins. The bacterial cell wall component lipopolysaccharide (LPS) s...