Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities

• Main Authors: Zaccaro M.C., Hong B.L., Pattarawarapan M., Xia Z., Caron A., L'Heureux P.-J., Bengio Y., Burgess K., Saragovi H.U.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-25144497042&partnerID=40&md5=a59ebb549be28665120e98ff970a0621; http://cmuir.cmu.ac.th/handle/6653943832/4949
• Institution: Chiang Mai University

We designed a minilibrary of 55 small molecule peptidomimetics based on β-turns of the neurotrophin growth factor polypeptides neurotrophin-3 (NT-3) and nerve growth factor (NGF). Direct binding, binding competition, and biological screens identified agonistic ligands of the ectodomain of the neurot...