Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance

• Main Authors: Wisinee Chanmahasathien, Chadarat Ampasavate, Harald Greger, Pornngarm Limtrakul
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78651336302&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49745
• Institution: Chiang Mai University

P-glycoprotein-mediated drug efflux can cause a multidrug resistance (MDR) phenotype that is associated with a poor response to cancer chemotherapy. Through bioassay-guided fractionation, active Stemona alkaloids were isolated from the roots of Stemona aphylla and S. burkillii. The chemical structur...