N,N,N-Trimethyl chitosan nanoparticles for the delivery of monoclonal antibodies against hepatocellular carcinoma cells

• Main Authors: Preeyanat Vongchan, Yupanan Wutti-In, Warayuth Sajomsang, Pattarapond Gonil, Suchart Kothan, Robert J. Linhardt
• Format: Journal
• Published: 2018
• Subjects: Chemistry; Materials Science
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79953672031&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49838
• Institution: Chiang Mai University

N,N,N-Trimethyl chitosan chloride is capable of forming nanocomplexes with protein through ionotropic gelation. A monoclonal antibody, raised against human liver heparan sulfate proteoglycan and specifically inhibiting hepatocellular carcinoma in vitro, was prepared in nanocomplexes of this modified...