A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4...

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Bibliographic Details
Main Authors: Kanchana Pumsalid, Haruthai Thaisuchat, Chatchanok Loetchutinat, Narong Nuntasaen, Puttinan Meepowpan, Wilart Pompimon
Format: Journal
Published: 2018
Subjects:
Agricultural and Biological Sciences
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751539201&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409
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Institution: Chiang Mai University
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Summary:Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control.

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