A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

• Main Authors: Kanchana Pumsalid, Haruthai Thaisuchat, Chatchanok Loetchutinat, Narong Nuntasaen, Puttinan Meepowpan, Wilart Pompimon
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751539201&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409
• Institution: Chiang Mai University

Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4...