A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4...

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Main Authors:	Kanchana Pumsalid, Haruthai Thaisuchat, Chatchanok Loetchutinat, Narong Nuntasaen, Puttinan Meepowpan, Wilart Pompimon
Format:	Journal
Published:	2018
Subjects:	Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751539201&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-50409
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spelling	th-cmuir.6653943832-504092018-09-04T04:52:30Z A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity Kanchana Pumsalid Haruthai Thaisuchat Chatchanok Loetchutinat Narong Nuntasaen Puttinan Meepowpan Wilart Pompimon Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control. 2018-09-04T04:40:47Z 2018-09-04T04:40:47Z 2010-12-01 Journal 15559475 1934578X 2-s2.0-78751539201 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751539201&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics Kanchana Pumsalid Haruthai Thaisuchat Chatchanok Loetchutinat Narong Nuntasaen Puttinan Meepowpan Wilart Pompimon A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
description	Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50values in the range of 2.64-3.58 μg.mL-1for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control.
format	Journal
author	Kanchana Pumsalid Haruthai Thaisuchat Chatchanok Loetchutinat Narong Nuntasaen Puttinan Meepowpan Wilart Pompimon
author_facet	Kanchana Pumsalid Haruthai Thaisuchat Chatchanok Loetchutinat Narong Nuntasaen Puttinan Meepowpan Wilart Pompimon
author_sort	Kanchana Pumsalid
title	A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_short	A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_full	A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_fullStr	A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_full_unstemmed	A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_sort	new azafluorenone from the roots of polyalthia cerasoides and its biological activity
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751539201&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50409
_version_	1681423584638009344

A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

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