A dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways

• Main Authors: Kanokkarn Phromnoi, Simone Reuter, Bokyung Sung, Pornngarm Limtrakul, Bharat B. Aggarwal
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77958572996&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50542
• Institution: Chiang Mai University

We sought to determine the molecular basis for the anticancer activities of 5,3′-dihydroxy-3,6,7,8,4′-penta-methoxyflavone (DH-PMF), isolated from Gardenia obtusifolia traditionally used in Thailand for a variety of ailments. As little as 1 μM DH-PMF inhibited the proliferation of prostate, colon, k...