Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage

• Main Authors: Chizuru Akatsu, Duriya Fongmoon, Shuji Mizumoto, Jean Claude Jacquinet, Prachya Kongtawelert, Shuhei Yamada, Kazuyuki Sugahara
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955599594&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50579
• Institution: Chiang Mai University

Glycosaminoglycans (GAGs) like chondroitin sulfate (CS) and heparan sulfate (HS) are synthesized on the tetrasaccharide linkage region, GlcAβ1-3Galβ1-3Galβ1-4Xylβ1-O-Ser, of proteoglycans. The Xyl can be modified by 2-O-phosphate in both CS and HS, whereas the Gal residues can be sulfated at C-4 and...