Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy
Urotensin II (UII) is a potential mediator in the pathogenesis of cardiovascular disease, and inhibition of its actions at the urotensin receptor (UT) has been shown to improve cardiac function and structural changes of the myocardium in a model of myocardial infarction. In this study we utilized a...
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th-cmuir.6653943832-506252018-09-04T04:52:18Z Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy Andrew R. Kompa Bing H. Wang Arintaya Phrommintikul Pei Y. Ho Darren J. Kelly David J. Behm Stephen A. Douglas Henry Krum Biochemistry, Genetics and Molecular Biology Neuroscience Urotensin II (UII) is a potential mediator in the pathogenesis of cardiovascular disease, and inhibition of its actions at the urotensin receptor (UT) has been shown to improve cardiac function and structural changes of the myocardium in a model of myocardial infarction. In this study we utilized a model of pressureoverload hypertrophy induced by abdominal aortic constriction (AAC) which resulted in hypertrophy, increased fibrosis and impaired diastolic and systolic function. These changes were associated with a 4-fold increase in UII protein expression in the myocardium. Treatment of animals with a selective UT (SB-657510) antagonist for 20 weeks at a dose of 1500ppm did not improve cardiac function as assessed by echocardiography and pressure-volume loop analysis, nor did it inhibit left ventricular hypertrophy or fibrosis. We hypothesize that other neurohumoral pathways may have a greater involvement in the pathogenesis of this model. Targeting the UII system appears to be insufficient to observe a beneficial outcome. © 2010 Elsevier Inc. 2018-09-04T04:43:02Z 2018-09-04T04:43:02Z 2010-01-01 Journal 01969781 2-s2.0-78249263484 10.1016/j.peptides.2010.04.026 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78249263484&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50625 |
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Biochemistry, Genetics and Molecular Biology Neuroscience Andrew R. Kompa Bing H. Wang Arintaya Phrommintikul Pei Y. Ho Darren J. Kelly David J. Behm Stephen A. Douglas Henry Krum Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy |
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Urotensin II (UII) is a potential mediator in the pathogenesis of cardiovascular disease, and inhibition of its actions at the urotensin receptor (UT) has been shown to improve cardiac function and structural changes of the myocardium in a model of myocardial infarction. In this study we utilized a model of pressureoverload hypertrophy induced by abdominal aortic constriction (AAC) which resulted in hypertrophy, increased fibrosis and impaired diastolic and systolic function. These changes were associated with a 4-fold increase in UII protein expression in the myocardium. Treatment of animals with a selective UT (SB-657510) antagonist for 20 weeks at a dose of 1500ppm did not improve cardiac function as assessed by echocardiography and pressure-volume loop analysis, nor did it inhibit left ventricular hypertrophy or fibrosis. We hypothesize that other neurohumoral pathways may have a greater involvement in the pathogenesis of this model. Targeting the UII system appears to be insufficient to observe a beneficial outcome. © 2010 Elsevier Inc. |
format |
Journal |
author |
Andrew R. Kompa Bing H. Wang Arintaya Phrommintikul Pei Y. Ho Darren J. Kelly David J. Behm Stephen A. Douglas Henry Krum |
author_facet |
Andrew R. Kompa Bing H. Wang Arintaya Phrommintikul Pei Y. Ho Darren J. Kelly David J. Behm Stephen A. Douglas Henry Krum |
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Andrew R. Kompa |
title |
Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy |
title_short |
Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy |
title_full |
Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy |
title_fullStr |
Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy |
title_full_unstemmed |
Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy |
title_sort |
chronic urotensin ii receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy |
publishDate |
2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78249263484&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50625 |
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1681423623473070080 |