Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy

• Main Authors: Andrew R. Kompa, Bing H. Wang, Arintaya Phrommintikul, Pei Y. Ho, Darren J. Kelly, David J. Behm, Stephen A. Douglas, Henry Krum
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Neuroscience
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78249263484&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50625
• Institution: Chiang Mai University

Urotensin II (UII) is a potential mediator in the pathogenesis of cardiovascular disease, and inhibition of its actions at the urotensin receptor (UT) has been shown to improve cardiac function and structural changes of the myocardium in a model of myocardial infarction. In this study we utilized a...