Quercetin, quercetrin except rutin potentially increased pirarubicin cytotoxicity by non-competitively inhibiting the P-glycoprotein-and MRP1 function in living K562/adr and GLC4/adr cells

• Main Authors: Winit Choiprasert, Nathupakorn Dechsupa, Suchart Kothan, Manuel Garrigos, Samlee Mankhetkorn
• Format: Journal
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77949890664&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51133
• Institution: Chiang Mai University

Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combin...