Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling

• Main Authors: Kattareeya Kumthip, Pattranuch Chusri, Nikolaus Jilg, Lei Zhao, Dahlene N. Fusco, Hong Zhao, Kaku Goto, Du Cheng, Esperance A. Schaefer, Leiliang Zhang, Chansom Pantip, Satawat Thongsawat, Amornrat O'Brien, Lee F. Peng, Niwat Maneekarn, Raymond T. Chung, Wenyu Lin
• Format: Journal
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Immunology and Microbiology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865086668&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/51262
• Institution: Chiang Mai University

Responses to alpha interferon (IFN-α)-based treatment are dependent on both host and viral factors and vary markedly among patients infected with different hepatitis C virus (HCV) genotypes (GTs). Patients infected with GT3 viruses consistently respond better to IFN treatment than do patients infect...