Cisplatin-induced ototoxicity in pediatric solid tumors: The role of glutathione S-transferases and megalin genetic polymorphisms

• Main Authors: Worawut Choeyprasert, Rachchadol Sawangpanich, Krisna Lertsukprasert, Umaporn Udomsubpayakul, Duantida Songdej, Usanarat Unurathapan, Samart Pakakasama, Suradej Hongeng
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878653311&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52874
• Institution: Chiang Mai University

Cisplatin-induced ototoxicity, an important dose-limiting side effect, has proven high interindividual variability. Glutathione S-transferases (GSTs) are isoenzymes involved in cellular detoxification processes. Megalin has been demonstrated to bind aminoglycosides, known to be similar to cisplatin...