Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters
This report describes the synthesis of four novel paclitaxel based prodrugs with glycan conjugation (1-4). Glycans were conjugated using an ester or ether bond as the linker between 2′-paclitaxel and the 2′-glucose or glucuronic acid moiety. These prodrugs showed good water solubility and selective...
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Main Authors: | Lin Y.-S., Tungpradit R., Sinchaikul S., An F.-M., Liu D.-Z., Phutrakul S., Chen S.-T. |
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Format: | Article |
Language: | English |
Published: |
2014
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Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-57349142938&partnerID=40&md5=af30ca40aab2c5becd270511b5bc1fb3 http://cmuir.cmu.ac.th/handle/6653943832/5343 |
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Institution: | Chiang Mai University |
Language: | English |
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