Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters

This report describes the synthesis of four novel paclitaxel based prodrugs with glycan conjugation (1-4). Glycans were conjugated using an ester or ether bond as the linker between 2′-paclitaxel and the 2′-glucose or glucuronic acid moiety. These prodrugs showed good water solubility and selective...

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Bibliographic Details
Main Authors: Lin Y.-S., Tungpradit R., Sinchaikul S., An F.-M., Liu D.-Z., Phutrakul S., Chen S.-T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-57349142938&partnerID=40&md5=af30ca40aab2c5becd270511b5bc1fb3
http://cmuir.cmu.ac.th/handle/6653943832/5343
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Institution: Chiang Mai University
Language: English

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