Ph<inf>3</inf>P/I<inf>2</inf>-mediated synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines
© 2016 Elsevier Ltd A convenient one-pot protocol for the synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines is reported. In the presence of the Ph3P–I2/Et3N system, a variety of secondary amides were smoothly reacted with primary or secondary amines to afford the corresponding amidi...
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| Main Authors: | , , , |
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| Format: | Journal |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84994028119&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/55261 |
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| Institution: | Chiang Mai University |
| Summary: | © 2016 Elsevier Ltd A convenient one-pot protocol for the synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines is reported. In the presence of the Ph3P–I2/Et3N system, a variety of secondary amides were smoothly reacted with primary or secondary amines to afford the corresponding amidines in good to excellent yields under mild conditions. |
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