Ph<inf>3</inf>P/I<inf>2</inf>-mediated synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines

• Main Authors: Wong Phakhodee, Sirilak Wangngae, Nittaya Wiriya, Mookda Pattarawarapan
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84994028119&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/55261
• Institution: Chiang Mai University

© 2016 Elsevier Ltd A convenient one-pot protocol for the synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines is reported. In the presence of the Ph3P–I2/Et3N system, a variety of secondary amides were smoothly reacted with primary or secondary amines to afford the corresponding amidi...