Sulfonation of papain-treated chitosan and its mechanism for anticoagulant activity

• Main Authors: Suwan J., Zhang Z., Li B., Vongchan P., Meepowpan P., Zhang F., Mousa S.A., Mousa S., Premanode B., Kongtawelert P., Linhardt R.J.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-66649109421&partnerID=40&md5=672381a5fcbe04a59556100de1650ff7; http://www.ncbi.nlm.nih.gov/pubmed/19476923; http://cmuir.cmu.ac.th/handle/6653943832/5853
• Institution: Chiang Mai University

The novel low-molecular-weight chitosan polysulfate (MW 5120-26,200 Da) was prepared using the depolymerization of chitosan with papain (EC. 3.4.22.2). The sulfonation of depolymerized products was performed using chlorosulfonic acid in N,N-dimethylformamide under semi-heterogeneous conditions. The...