Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission

Mother-to-child transmission (MTCT) of HIV-1 provides a model for studying the role of passively acquired antibodies in preventing HIV infection. We determined the titers of neutralizing antibodies (NAbs) against six primary isolates of clades B and CRF01_AE in sera from 45 transmitting and 45 nontr...

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Main Authors: Tanawan Samleerat, Suzie Thenin, Gonzague Jourdain, Nicole Ngo-Giang-Huong, Alain Moreau, Pranee Leechanachai, Jirapan Ithisuknanth, Karin Pagdi, Pornpun Wannarit, Suraphan Sangsawang, Marc Lallemant, Francis Barin, Martine Braibant
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/59636
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-596362018-09-10T03:18:41Z Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission Tanawan Samleerat Suzie Thenin Gonzague Jourdain Nicole Ngo-Giang-Huong Alain Moreau Pranee Leechanachai Jirapan Ithisuknanth Karin Pagdi Pornpun Wannarit Suraphan Sangsawang Marc Lallemant Francis Barin Martine Braibant Immunology and Microbiology Mother-to-child transmission (MTCT) of HIV-1 provides a model for studying the role of passively acquired antibodies in preventing HIV infection. We determined the titers of neutralizing antibodies (NAbs) against six primary isolates of clades B and CRF01_AE in sera from 45 transmitting and 45 nontransmitting mothers matched for the main independent factors associated with MTCT in Thailand. A lower risk of MTCT, particularly for intrapartum transmission, was associated only with higher NAb titers against the CRF01_AE strain, MBA. The envelope glycoprotein of this strain showed an unusually long V2 domain of 63 amino acids, encoding six potential N-linked glycosylation sites. We provided experimental data indicating that the extended V2 domain contributed to the higher level of resistance to neutralization by mothers' sera in this strain. Taken together the data suggest that some primary isolates with specific properties may be useful indicators for identifying protective antibodies. © 2009 Elsevier Inc. All rights reserved. 2018-09-10T03:18:41Z 2018-09-10T03:18:41Z 2009-05-10 Journal 10960341 00426822 2-s2.0-64849106636 10.1016/j.virol.2009.02.024 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=64849106636&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/59636
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Immunology and Microbiology
spellingShingle Immunology and Microbiology
Tanawan Samleerat
Suzie Thenin
Gonzague Jourdain
Nicole Ngo-Giang-Huong
Alain Moreau
Pranee Leechanachai
Jirapan Ithisuknanth
Karin Pagdi
Pornpun Wannarit
Suraphan Sangsawang
Marc Lallemant
Francis Barin
Martine Braibant
Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission
description Mother-to-child transmission (MTCT) of HIV-1 provides a model for studying the role of passively acquired antibodies in preventing HIV infection. We determined the titers of neutralizing antibodies (NAbs) against six primary isolates of clades B and CRF01_AE in sera from 45 transmitting and 45 nontransmitting mothers matched for the main independent factors associated with MTCT in Thailand. A lower risk of MTCT, particularly for intrapartum transmission, was associated only with higher NAb titers against the CRF01_AE strain, MBA. The envelope glycoprotein of this strain showed an unusually long V2 domain of 63 amino acids, encoding six potential N-linked glycosylation sites. We provided experimental data indicating that the extended V2 domain contributed to the higher level of resistance to neutralization by mothers' sera in this strain. Taken together the data suggest that some primary isolates with specific properties may be useful indicators for identifying protective antibodies. © 2009 Elsevier Inc. All rights reserved.
format Journal
author Tanawan Samleerat
Suzie Thenin
Gonzague Jourdain
Nicole Ngo-Giang-Huong
Alain Moreau
Pranee Leechanachai
Jirapan Ithisuknanth
Karin Pagdi
Pornpun Wannarit
Suraphan Sangsawang
Marc Lallemant
Francis Barin
Martine Braibant
author_facet Tanawan Samleerat
Suzie Thenin
Gonzague Jourdain
Nicole Ngo-Giang-Huong
Alain Moreau
Pranee Leechanachai
Jirapan Ithisuknanth
Karin Pagdi
Pornpun Wannarit
Suraphan Sangsawang
Marc Lallemant
Francis Barin
Martine Braibant
author_sort Tanawan Samleerat
title Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission
title_short Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission
title_full Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission
title_fullStr Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission
title_full_unstemmed Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission
title_sort maternal neutralizing antibodies against a crf01_ae primary isolate are associated with a low rate of intrapartum hiv-1 transmission
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=64849106636&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/59636
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